

Guy Ecker as Joe Navarro (season 6–present), ONDCP director and the DEA administrator in México after Colon.Miguel Varoni as Leandro Quezada (season 5–6), Leader of the Santa Norma Cartel.El Chema's former lover, Gary Robert's Widow. Mariana Seoane as Mabel Castaño / Ninón del Valle ( season 5).Marisela González as Eunice Lara "La Felina" (season 5, recurring season 4).Vanessa Villela as Emiliana Contreras (seasons 4–5), Lencho's daughter.Sabrina Seara as Esperanza Salvatierra (seasons 4–5, recurring season 3), Aurelio's Ex-lover.Maritza Rodríguez as Amparo Rojas (seasons 3–4).Ana Sofía Durán as Child Rutila (season 2).Terina Angell as Child Rutila (season 1).Carmen Aub as Rutila Casillas (seasons 3–7 recurring season 2), Heriberto's and Luzma's sister.Marlene Favela as Victoria Navárez (season 2), Daughter of Governor Pedro Navárez and later Governor of Jalisco.Fernanda Castillo as Mónica Robles (seasons 2–5 recurring season 1).Alberto Guerra as El Chema (season 6 recurring season 7).Mauricio Ochmann as El Chema (seasons 2–3 special guest stars season 1), Leader of the Venegas cartel, Leonardo and El Chemita's father, El Rojo’s adoptive brother, Aurelio’s ally and rival, Fabricio Ponce’s big enemy, Ricardo Almenar’s enemy and rival.
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Carmen Villalobos as Leonor Ballesteros (seasons 2–3 recurring season 1), Colombian infiltrated agent and the female protagonist of the series during seasons 2–3.Gabriel Porras as Marco Mejía ( season 1), commander obsessed with capturing Aurelio Casillas.Aurelio's brother, and Víctor and Carlo's father, Aurelio’s second-in-command and right hand man.

